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91.
高效液相色谱法测定人血清中酒石酸美托洛尔浓度 总被引:5,自引:0,他引:5
目的:建立测定人血清中酒石酸美托洛尔浓度的HPLC方法,为临床药理研究提供科学的分析技术。方法:血清样品萃取纯化后溶于流动相中,进样分析。测定使用C18色谱柱,甲醇-水相(50:50,水相中含0.16%戊烷磺酸钠和0.014%无水乙酸钠)为流动相,以纳多洛尔为内标,用荧光检测Ex=277nm,Em=299nm。结果:本方法线性范围为10~300ng/ml,最低检测浓度为1ng/ml。平均回收率为( 相似文献
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O Rollman 《Dermatologica》1982,165(1):54-61
13 patients with distal subungual onychomycosis in a total of 48 dermatophyte-infected nails were treated with chemomechanical, partial nail avulsion followed by topical miconazole for 8 weeks. On examination, 6 months after cessation of therapy, 42% of the nails were cured by clinical and mycological criteria. The therapeutic response was related to the pretreatment extension of subungual hyperkeratosis. Periungual skin irritation was common during the initial avulsion period. Miconazole solution was well tolerated and this treatment modality proved to be a valuable alternative to other remedies for the treatment of onychomycosis limited to a few number of nails. 相似文献
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Steven D. Weisbord Anne Marie Shields Maria K. Mor Mary Ann Sevick Marcia Homer Janet Peternel Patricia Porter Bruce L. Rollman Paul M. Palevsky Robert M. Arnold Michael J. Fine 《Contemporary clinical trials》2010,31(5):491-497
Despite the high prevalence of pain, sexual dysfunction, and depression in patients on chronic hemodialysis, these symptoms are often unrecognized and under-treated by renal providers. This report describes the rationale and methodology of the SMILE study (Symptom Management Involving End-Stage Renal Disease), a multi-center, randomized clinical trial comparing the effectiveness of two strategies for implementing treatment for these symptoms in patients receiving chronic hemodialysis. Approximately 250 patients from nine outpatient dialysis units will participate. Over a 2–12 month observational phase, participants complete monthly surveys characterizing their pain, sexual dysfunction, and depression. Following this observational period, subjects are randomized to one of two study arms to receive a 12-month intervention. In one study arm (feedback intervention), patients continue to complete the same three symptom surveys, and the presence and severity of the symptoms reported on these surveys is mailed to the patient's renal provider along with evidence-based algorithms outlining treatment options for these symptoms. Decisions on treatment are left at the discretion of the provider. Patients randomized to the other study arm (management intervention) also continue to complete the same monthly symptom surveys and are evaluated by a symptom management nurse trained in the management of these symptoms. This nurse then discusses the patient's symptoms with the renal provider, provides specific recommendations for treatment, and facilitates the implementation of treatment. The primary endpoints are changes in scores on pain, erectile dysfunction, and depression surveys. This report describes the rationale and methodology of this clinical trial. 相似文献
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Natalia E. Morone MD MS Bea Herbeck Belnap Dr. Biol. Hum Fanyin He BS Sati Mazumdar PhD Debra K. Weiner MD Bruce L. Rollman MD MPH 《Journal of general internal medicine》2013,28(1):58-66